chemotactic factors การใช้

• OPN was also found to act as a macrophage chemotactic factor.
• FMLP is the prototypical representative of the N-fomylated oligopeptide family of chemotactic factors.
• BDNF can function as a chemotactic factor for neural precursors during migration by activating TrkB receptors.
• After the release of vasoactive and chemotactic factors, angiogenesis and the proliferation of tenocytes are initiated.
• Brain-derived neurotrophic factor is among the chemotactic factors that stimulate Numb-mediated chemotaxis during cell migration.
• Snyderman discovered C5a, a major chemotactic factor responsible for white blood cell accumulation and vascular permiability at sites of inflammation.
• Second, as inflammation nears completion, macrophage and mast cells release fibroblast growth and chemotactic factors to activate fibroblasts from adjacent tissue.
• Segal and her colleagues identified a factor brain-derived neurotrophic factor ( BDNF ) as a chemotactic factor that controls neuron migration.
• These studies indicate that Alox5 can serve a protective function presumably by generating metabolites such as chemotactic factors that mobilize the innate immunity system.
• Ectodomain shedding results in the soluble mature form of HB-EGF, which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts.
• The promastigote forms also release " Leishmania " chemotactic factor ( LCF ) to actively recruit neutrophils, but not other leukocytes, for instance monocytes or NK cells.
• These genetic studies allow that ALOX5 along with the chemotactic factors and SPMs that they contribute to making may play similar opposing pro-inflammatory and anti-inflammatory functions in humans.
• This may be a reflection of the array of metabolites made by the Alox5 enzyme some of which possess opposing activities like the pro-inflammatory chemotactic factors and the anti-inflammatory specialized pro-resolving mediators.
• For example, chemotactic factors stimulate human neutrophils to raise cytosolic Ca 2 + which triggers cPLA 2 s, particularly the ? isoform ( cPLA 2 ? ), to move from its normal residence in the cytosol to cellular membranes.
• Both receptor types bind and are activated by a series of formylated oligopeptide chemotactic factors but FLP2 receptor appears to be a promiscuous receptor in that it also binds to and is activated by lipoxins and resolvins as well as various polypeptides and proteins.
• This branch of the complement system is activated by IgA immune complexes and bacterial endotoxins, polysaccharides, and cell walls, and results in producing anaphylatoxins, opsonins, chemotactic factors, and the membrane attack complex, all of which help fight pathogens.
• Thus, bacteria produce a family of oligopeptide chemotactic factors plus activate host complement pathways to generate C5a, which, like the formylated oligopeptides, is a neutrophil chemotactic factor that operates through receptors whose genes cluster with those for the three formly peptide receptors.
• Thus, bacteria produce a family of oligopeptide chemotactic factors plus activate host complement pathways to generate C5a, which, like the formylated oligopeptides, is a neutrophil chemotactic factor that operates through receptors whose genes cluster with those for the three formly peptide receptors.
• LTB4, 5-HETE, and 5-oxoETE may contribute to the innate immune response as leukocyte chemotactic factors, i . e . they recruit and further activate circulating blood neutrophils and monccytes to sites of microbial invasion, tissue injury, and foreign bodies.
• T20 is also an activator of the chemotactic factor receptor, "'formyl peptide receptor 1 "'( "'FPR1 "'), and thereby activates phaogocytes and presumably other cells bearing this receptor ( See Formyl peptide receptors section on FPR1 receptors ).